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The Lab 



Welcome to the Topf Lab at the CSSB Hamburg! We work on the development of integrative structural methods, combining experimental data, bioinformatics and modelling techniques, to characterise the structures of macromolecular assemblies. Structural models are further analysed to understand their function and design new experiments.   


The group is particularly interested in using data from cryoEM, cryoET, and Mass Spectrometry. In collaboration with experimentalists, we focus on characterising assemblies in different virus families, including herpesviruses and arenaviruses. 


Latest Publications

Modeling flexible protein structure with AlphaFold2 and cross-linking mass spectrometry

Manalastas-Cantos K, Adoni KR, Pfeifer M, Märtens B, Grünewald K, Thalassinos K, Topf M. (2024)

Mol Cell Proteomics 100724.

DOI: 10.1016/j.mcpro.2024.100724.


CSSB - Centre for Structural Systems Biology 

c/o DESY, Building 15

Notkestr. 85

22607 Hamburg, Germany

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